What is Attr-CM?

It’s a life-threatening, underdiagnosed disease that’s associated with heart failure, so it’s important to Get the Message and talk to your doctor if you think you or a loved one might have ATTR-CM.

Here’s what happens in your body when you have ATTR-CM:

1. Transthyretin, a normal transport protein, becomes unstable

2. The unstable protein misfolds, creating
amyloid fibrils which can build up in your heart and other parts of your body

3. The buildup causes the heart muscle to stiffen over time, eventually leading to heart failure

There Are Two Sub-types of ATTR-CM

Wild-type ATTR-CM (wtATTR) is associated with aging:

  • It’s not caused by a genetic mutation
  • Is thought to be the most common form of ATTR-CM
  • Most often affects men over the age of 60

Hereditary, or variant ATTR-CM (hATTR), is inherited from a relative:

  • It’s caused by a mutation in the gene that produces the transthyretin protein
  • Affects both men and women, with symptom onset occurring in people as early as their 50s or 60s
  • In the U.S., the most common type (V122I) is found almost exclusively in African Americans
  • People with the genetic mutation may never actually develop symptoms

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