ATTR-CM (transthyretin amyloid cardiomyopathy) is a rare, serious, underrecognized and underdiagnosed type of amyloidosis that affects the heart and is associated with heart failure.

See what happens inside your body when you have ATTR-CM

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The liver produces transthyretin, a transport protein that carries the hormone thyroxine and vitamin A (retinol) throughout the bloodstream.
When someone has ATTR-CM, either due to aging (wild-type) or an inherited genetic variant (hereditary), the protein becomes unstable and misfolds.
Over time, the misfolded proteins join together and build up in the body, including in the heart (causing the heart muscle to thicken and stiffen, eventually leading to heart failure).

There Are 2 types of ATTR-CM


Wild-type ATTR-CM (wtATTR):

  • Associated with aging
  • Most often affects white men over the age of 60
  • May be the most common form of ATTR-CM

Hereditary ATTR-CM (hATTR):

  • Caused by a change (or “mutation”) in one of your genes
  • Passed down from a relative
  • Affects both men and women, with symptoms beginning as early as 50 to 60 years old
  • There are more than 120 known mutations that cause hATTR; the most common mutation in the United States is V122i

V122i Almost Exclusively Affects African Americans

In the United States, the V122i mutation is found almost exclusively in individuals of African ancestry. Approximately 3% to 4% of the African American population are thought to be carriers of the mutation. However, not all individuals with a mutation develop symptoms of hereditary ATTR-CM.

Learn more about hereditary ATTR-CM and Voices for the Heart community events


Learn more about hereditary ATTR-CM and how this disease has affected former NBA player and coach, Don Chaney.

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ATTR-CM could be the underlying cause of your heart failure, so it’s important to recognize the messages your body may be sending.

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