see the bigger picture

when to suspect

How can you tell if you or someone you love might have ATTR‑CM?

Understand the signs

and symptoms

There are cardiac and noncardiac symptoms of transthyretin cardiac amyloidosis (ATTR‑CM). See if your symptoms are listed.

These examples are for illustrative purposes only. Signs and symptoms may vary from patient to patient.


(excessive tiredness)

“I’m tired all of the time.”

Tendon Rupture

(eg, biceps, Achilles tendon)

“There is a painful lump in my upper arm.”

Stomach Issues

(eg, diarrhea, constipation, nausea, or feeling full quickly)

“It seems like my stomach is more sensitive lately.”

Shoulder, Hip, and/or Knee Pain

“It’s been years since I had my hip replaced.”

Swelling in Lower Legs

(known as peripheral edema)

“My lower legs and feet look swollen and puffy all the time these days.”

Eye Disorders

(eg, glaucoma)

“I have a past medical history of glaucoma.”

Shortness of Breath

“Sometimes I feel like I can't catch my breath.”

Irregular Heartbeat

(known as cardiac arrhythmia)

“My doctor says I have an abnormal heartbeat.”

Bilateral Carpal Tunnel Syndrome

(numbness, tingling, or pain in your fingers)

“I’ve had carpal tunnel syndrome in both wrists for years now.”

Pain or Numbness in Lower Back or Legs Due to Narrowing of Lower Spine

(known as lumbar spinal stenosis)

“My doctor told me my back pain is caused by something called lumbar spinal stenosis.”

Decreased Sensation or Strange Tingling or Pain in Toes or Feet

(known as peripheral neuropathy)

“It feels like my feet are always falling asleep.”

If you have heart failure and experience any of these symptoms, talk to your cardiologist about ATTR‑CM. The more your doctor knows about what you are experiencing, the better they can help you get many of the answers you need.

Hear how real patients recognized their symptoms

“I started retaining fluid in my legs.”

– Faye



“I had numbness and tingling in my arms.”

– Dempsey



“My first sign was carpal tunnel syndrome.”

– Walt

In memory of Walt, a passionate advocate (1948-2022)



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